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Adv Exp Med Biol. 2009;667:53-8.

The lipid A receptor.

Author information

  • 1Department of Molecular Genetics, Medical Institute of Bioregulation, Kyushu University, 3-1-1 Maidashi, Higashi-ku, Fukuoka, 812-8582, Japan. ktakeda@bioreg.kyushu-u.ac.jp

Abstract

The lipid A receptor consists of several subunits. Lipopolysaccharide binding protein (LBP) is a serum protein facilitating association of lipid A with CD14. The Lipid A-LBP-CD14 complex is further delivered to Toll-like receptor 4 (TLR4), which is essential for lipid A-mediated cellular activation. TLR4 associates with MD-2, which is required for surface expression and recognition of lipid A. In addition, the RP105-MD-1 complex mediates TLR4-mediated response in B cells and negatively regulates TLR4-mediated response in dendritic cells. Thus, lipid A receptor's function varies among cell populations.

PMID:
20429216
[PubMed - indexed for MEDLINE]
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