Curr Gastroenterol Rep. 2010 Jun;12(3):215-22. doi: 10.1007/s11894-010-0108-1.

Etiology of esophageal atresia and tracheoesophageal fistula: "mind the gap".

de Jong EM, Felix JF, de Klein A, Tibboel D.

Source

Department of Pediatric Surgery, Erasmus MC-Sophia Children's Hospital, PO Box 2060, 3000 CB, Rotterdam, The Netherlands. e.m.dejong@erasmusmc.nl

Abstract

Esophageal atresia and tracheoesophageal fistula (EA/TEF) are major congenital malformations affecting 1:3500 live births. Current research efforts are focused on understanding the etiology of these defects. We describe well-known animal models, human syndromes, and associations involving EA/TEF, indicating its etiologically heterogeneous nature. Recent advances in genotyping technology and in knowledge of human genetic variation will improve clinical counseling on etiologic factors. This review provides a clinical summary of environmental and genetic factors involved in EA/TEF.

PMID:: 20425471; [PubMed - indexed for MEDLINE]
PMCID:: PMC2874026

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Cited by 3 PubMed Central articles

[Association esophageal atresia type 3 - microcephaly: an incomplete Feingold syndrome?]. [Pan Afr Med J. 2012]
[Association esophageal atresia type 3 - microcephaly: an incomplete Feingold syndrome?].
Shongo MY, Lubala TK, Mbuyi SM, Makinko PI, Ngwej DT, Kabange FN. Pan Afr Med J. 2012; 13:85. Epub 2012 Dec 20.
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Etiology of esophageal atresia and tracheoesophageal fistula: "mind the gap".
Etiology of esophageal atresia and tracheoesophageal fistula: "mind the gap".
Curr Gastroenterol Rep. 2010 Jun ;12(3):215-22. doi: 10.1007/s11894-010-0108-1.

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