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    Curr Osteoporos Rep. 2010 Mar;8(1):23-7.

    Anabolic therapies.

    Lane NE, Silverman SL.

    Source

    Aging Center, Medicine and Rheumatology, University of California at Davis Medical Center, 4800 2nd Avenue, Suite 2600, Sacramento, CA 95817, USA. nancy.lane@ucdmc.ucdavis.edu

    Abstract

    The striking clinical benefits of intermittent parathyroid hormone in osteoporosis have begun a new era of skeletal anabolic agents. Recombinant human parathyroid hormone (rhPTH) (1-34) is the first US Food and Drug Administration-approved anabolic therapy. Its use has been limited by the need for subcutaneous injection. Newer delivery systems include transdermal and oral preparations. Newer anabolic therapies include monoclonal antibody to sclerostin, a potent inhibitor of osteoblastogenesis; and use of bone morphogenetic proteins and parathyroid hormone-related protein PTHrP, a calcium-regulating hormone similar to PTH.

    PMID:
    20425087
    [PubMed - indexed for MEDLINE]
    PMCID:
    PMC2841260
    Free PMC Article

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      Cited by 2 PubMed Central articles

      • The Load-Bearing Mechanosome Revisited. [Clin Rev Bone Miner Metab. 2010]
        The Load-Bearing Mechanosome Revisited.
        Bidwell JP, Pavalko FM. Clin Rev Bone Miner Metab. 2010 Nov 11; 8(4):213-223.
      • Sclerostin. [J Osteoporos. 2010]
        Sclerostin.
        Silverman SL. J Osteoporos. 2010 Sep 29; 2010:941419. Epub 2010 Sep 29.

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