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Curr Allergy Asthma Rep. 2010 May;10(3):210-4. doi: 10.1007/s11882-010-0106-2.

Xenotropic murine leukemia virus-related virus in chronic fatigue syndrome and prostate cancer.

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  • Georgetown University, 3800 Reservoir Road NW, Washington, DC 20007-2197, USA. baraniuj@georgetown.edu

Abstract

Xenotropic murine leukemia virus-related virus (XMRV) is a gamma retrovirus that has been associated with chronic fatigue syndrome (CFS) and prostate cancer. The search for viral causes of these syndromes was reignited by the finding that RNase L activity was low in hereditary prostate cancer and some CFS patients. The six strains of XMRV that have been sequenced have greater than 99% identity, indicating a new human infection rather than laboratory contamination. DNA, RNA, and proteins from XMRV have been detected in 50% to 67% of CFS patients and in about 3.7% of healthy controls. XMRV infections could be transmitted to permissive cell lines from CFS plasma, suggesting the potential for communicable and blood-borne spread of the virus and potentially CFS. This troubling concept is currently under intense evaluation. The most important steps now are to independently confirm the initial findings; develop reliable assays of biomarkers; and to move on to investigations of XMRV pathophysiology and treatment in CFS, prostate cancer, and potentially other virus-related syndromes, if they exist.

PMID:
20425007
[PubMed - indexed for MEDLINE]
PMCID:
PMC2880572
Free PMC Article
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