Send to

Choose Destination
See comment in PubMed Commons below
Curr Hypertens Rep. 2010 Apr;12(2):86-92. doi: 10.1007/s11906-010-0094-6.

Modulation of pressure-natriuresis by renal medullary reactive oxygen species and nitric oxide.

Author information

  • 1Department of Physiology, Medical College of Wisconsin, Milwaukee, WI 53202, USA.


The renal pressure-natriuresis mechanism is the dominant controller of body fluid balance and long-term arterial pressure. In recent years, it has become clear that the balance of reactive oxygen and nitrogen species within the renal medullary region is a key determinant of the set point of the renal pressure-natriuresis curve. The development of renal medullary oxidative stress causes dysfunction of the pressure-natriuresis mechanism and contributes to the development of hypertension in numerous disease models. The purpose of this review is to point out the known mechanisms within the renal medulla through which reactive oxygen and nitrogen species modulate the pressure-natriuresis response and to update the reader on recent advances in this field.

[PubMed - indexed for MEDLINE]
Free PMC Article
PubMed Commons home

PubMed Commons

How to join PubMed Commons

    Supplemental Content

    Full text links

    Icon for Springer Icon for PubMed Central
    Loading ...
    Write to the Help Desk