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Org Biomol Chem. 2010 Jun 21;8(12):2777-83. doi: 10.1039/c001772h. Epub 2010 Apr 28.

Tuned methods for conjugate addition to a vinyl oxadiazole; synthesis of pharmaceutically important motifs.

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  • 1Department of Pure and Applied Chemistry, WestCHEM, University of Strathclyde, 295 Cathedral Street, Glasgow, Scotland, UKG1 1XL.


The addition of various nucleophiles to a vinyl 1,2,4-oxadiazole is described. Following optimisation, individual protocols tuned for the use of each specific class of reagent have been developed to allow the installation of nitrogen, sulfur, oxygen, and carbon nucleophiles, and leading to the preparation of a series of compounds containing the pharmaceutically important oxadiazole motif.

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