Send to:

Choose Destination
See comment in PubMed Commons below
J Chem Phys. 2010 Apr 21;132(15):154107. doi: 10.1063/1.3382349.

Large-scale simulations of fluctuating biological membranes.

Author information

  • 1Department of Chemistry, University of California, Berkeley, California 94720, USA.


We present a simple, and physically motivated, coarse-grained model of a lipid bilayer, suited for micron scale computer simulations. Each approximately 25 nm(2) patch of bilayer is represented by a spherical particle. Mimicking forces of hydrophobic association, multiparticle interactions suppress the exposure of each sphere's equator to its implicit solvent surroundings. The requirement of high equatorial density stabilizes two-dimensional structures without necessitating crystalline order, allowing us to match both the elasticity and fluidity of natural lipid membranes. We illustrate the model's versatility and realism by characterizing a membrane's response to a prodding nanorod.

[PubMed - indexed for MEDLINE]
Free PMC Article
PubMed Commons home

PubMed Commons

How to join PubMed Commons

    Supplemental Content

    Full text links

    Icon for American Institute of Physics Icon for PubMed Central
    Loading ...
    Write to the Help Desk