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J Chem Phys. 2010 Apr 21;132(15):154107. doi: 10.1063/1.3382349.

Large-scale simulations of fluctuating biological membranes.

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  • 1Department of Chemistry, University of California, Berkeley, California 94720, USA.

Abstract

We present a simple, and physically motivated, coarse-grained model of a lipid bilayer, suited for micron scale computer simulations. Each approximately 25 nm(2) patch of bilayer is represented by a spherical particle. Mimicking forces of hydrophobic association, multiparticle interactions suppress the exposure of each sphere's equator to its implicit solvent surroundings. The requirement of high equatorial density stabilizes two-dimensional structures without necessitating crystalline order, allowing us to match both the elasticity and fluidity of natural lipid membranes. We illustrate the model's versatility and realism by characterizing a membrane's response to a prodding nanorod.

PMID:
20423168
[PubMed - indexed for MEDLINE]
PMCID:
PMC3188600
Free PMC Article
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