Format

Send to

Choose Destination
See comment in PubMed Commons below
Curr Pharm Biotechnol. 2010 Aug;11(5):496-9.

MDMA administration and heat shock proteins response: foreseeing a molecular link.

Author information

  • 1Department of Forensic Pathology, University of Foggia, Viale degli Aviatori 1,71100 Foggia, Italy. cristoforopomara@hotmail.com

Abstract

Molecular and cellular mechanisms of MDMA-induced toxicity have been extensively studied in a number of experimental models. Nevertheless, only few studies investigated the involvement of HSPs ("molecular chaperones") in MDMA organs toxicity. In the present minireview we highlight this subject analysing the results of these studies conducted especially on brain tissue. Despite of it seems obvious that HSPs overexpression is a protective reaction against MDMA treatment, the molecular mechanisms for exerting their action are far to be undiscovered. At the same time, we need of comprehensive studies concerning the whole range of Hsps/chaperones expressions in all organs after acute and chronic administration of MDMA.

PMID:
20420569
[PubMed - indexed for MEDLINE]
PubMed Commons home

PubMed Commons

0 comments
How to join PubMed Commons

    Supplemental Content

    Full text links

    Icon for Bentham Science Publishers Ltd.
    Loading ...
    Write to the Help Desk