Warning: The NCBI web site requires JavaScript to function. more...

Sign in to NCBI

Result Filters

We are sorry, but NCBI web applications do not support your browser and may not function properly. More information

Eur J Cancer. 2010 Jul;46(10):1773-80. doi: 10.1016/j.ejca.2010.04.002. Epub 2010 Apr 24.

The biology and treatment of EML4-ALK non-small cell lung cancer.

Sasaki T, Rodig SJ, Chirieac LR, Jänne PA.

Source

Lowe Center for Thoracic Oncology, Dana-Farber Cancer Institute, Boston, MA 02115, USA.

Abstract

The fusion between echinoderm microtubule-associated protein-like 4 (EML4) and anaplastic lymphoma kinase (ALK) has recently been identified in a subset of non-small cell lung cancers (NSCLCs). EML4-ALK is most often detected in never smokers with lung cancer and has unique pathologic features. EML4-ALK is oncogenic both in vitro and in vivo and ALK kinase inhibitors are quite effective in pre-clinical model systems. More recently ALK inhibitors have entered clinical development and remarkably clinical efficacy has been observed in NSCLC patients harbouring EML4-ALK translocations. This review will focus on the biology, clinical characteristics, diagnosis and treatment of EML4-ALK NSCLC.

Copyright 2010 Elsevier Ltd. All rights reserved.

PMID:: 20418096; [PubMed - indexed for MEDLINE]
PMCID:: PMC2888755

Free PMC Article

Images from this publication.See all images (4)Free text

Publication Types, MeSH Terms, Substances, Grant Support

Publication Types

MeSH Terms

Substances

Grant Support

LinkOut - more resources

Full Text Sources

Other Literature Sources

COS Scholar Universe

Medical

Miscellaneous

See the articles recommended by F1000Prime's Faculty of 5,000 renowned researchers and clinicians, assisted by 5,000 associates. - F1000

Supplemental Content

Icon for Elsevier Science

Icon for PubMed Central

Save items

loading

Click here to read article using PubReader

Related citations in PubMed

Review [A new target in non-small cell lung cancer: EML4-ALK fusion gene]. [Zhongguo Fei Ai Za Zhi. 2011]
Review [A new target in non-small cell lung cancer: EML4-ALK fusion gene].
Wang H, Yuan J, Ma Z. Zhongguo Fei Ai Za Zhi. 2011 Jun; 14(6):538-42.
EML4-ALK rearrangement in non-small cell lung cancer and non-tumor lung tissues. [Am J Pathol. 2009]
EML4-ALK rearrangement in non-small cell lung cancer and non-tumor lung tissues.
Martelli MP, Sozzi G, Hernandez L, Pettirossi V, Navarro A, Conte D, Gasparini P, Perrone F, Modena P, Pastorino U, et al. Am J Pathol. 2009 Feb; 174(2):661-70. Epub 2009 Jan 15.
Therapeutic strategies to overcome crizotinib resistance in non-small cell lung cancers harboring the fusion oncogene EML4-ALK. [Proc Natl Acad Sci U S A. 2011]
Therapeutic strategies to overcome crizotinib resistance in non-small cell lung cancers harboring the fusion oncogene EML4-ALK.
Katayama R, Khan TM, Benes C, Lifshits E, Ebi H, Rivera VM, Shakespeare WC, Iafrate AJ, Engelman JA, Shaw AT. Proc Natl Acad Sci U S A. 2011 May 3; 108(18):7535-40. Epub 2011 Apr 18.
Exon array profiling detects EML4-ALK fusion in breast, colorectal, and non-small cell lung cancers. [Mol Cancer Res. 2009]
Exon array profiling detects EML4-ALK fusion in breast, colorectal, and non-small cell lung cancers.
Lin E, Li L, Guan Y, Soriano R, Rivers CS, Mohan S, Pandita A, Tang J, Modrusan Z. Mol Cancer Res. 2009 Sep; 7(9):1466-76. Epub 2009 Sep 8.
Review Non-solid oncogenes in solid tumors: EML4-ALK fusion genes in lung cancer. [Cancer Sci. 2008]
Review Non-solid oncogenes in solid tumors: EML4-ALK fusion genes in lung cancer.
Mano H. Cancer Sci. 2008 Dec; 99(12):2349-55. Epub 2008 Nov 20.

See reviews... See all...

Cited by 27 PubMed Central articles

Identification of Novel Variant of EML4-ALK Fusion Gene in NSCLC: Potential Benefits of the RT-PCR Method. [Int J Biomed Sci. 2012]
Identification of Novel Variant of EML4-ALK Fusion Gene in NSCLC: Potential Benefits of the RT-PCR Method.
Maus MK, Stephens C, Zeger G, Grimminger PP, Huang E. Int J Biomed Sci. 2012 Mar; 8(1):1-6.
Targeted resequencing reveals ALK fusions in non-small cell lung carcinomas detected by FISH, immunohistochemistry, and real-time RT-PCR: a comparison of four methods. [Biomed Res Int. 2013]
Targeted resequencing reveals ALK fusions in non-small cell lung carcinomas detected by FISH, immunohistochemistry, and real-time RT-PCR: a comparison of four methods.
Tuononen K, Sarhadi VK, Wirtanen A, Rönty M, Salmenkivi K, Knuuttila A, Remes S, Telaranta-Keerie AI, Bloor S, Ellonen P, et al. Biomed Res Int. 2013; 2013:757490. Epub 2013 Jan 20.
Gene mutations and molecularly targeted therapies in acute myeloid leukemia. [Am J Blood Res. 2013]
Gene mutations and molecularly targeted therapies in acute myeloid leukemia.
Hatzimichael E, Georgiou G, Benetatos L, Briasoulis E. Am J Blood Res. 2013; 3(1):29-51. Epub 2013 Jan 17.

Related information

Related Citations
Calculated set of PubMed citations closely related to the selected article(s) retrieved using a word weight algorithm. Related articles are displayed in ranked order from most to least relevant, with the “linked from” citation displayed first.
References for this PMC Article
Citation referenced in PubMed article. Only valid for PubMed citations that are also in PMC.
Free in PMC
Free full text articles in PMC
Cited in PMC
Full-text articles in the PubMed Central Database that cite the current articles.

Recent activity

Clear Turn Off Turn On

The biology and treatment of EML4-ALK non-small cell lung cancer.
The biology and treatment of EML4-ALK non-small cell lung cancer.
Eur J Cancer. 2010 Jul ;46(10):1773-80. doi: 10.1016/j.ejca.2010.04.002. Epub 2010 Apr 24 .

PubMed

Your browsing activity is empty.

Activity recording is turned off.

Turn recording back on

See more...

You are here: NCBI > Literature > PubMed

Write to the Help Desk