Eur J Cancer. 2010 Jul;46(10):1773-80. Epub 2010 Apr 24.

The biology and treatment of EML4-ALK non-small cell lung cancer.

Sasaki T, Rodig SJ, Chirieac LR, Jänne PA.

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Lowe Center for Thoracic Oncology, Dana-Farber Cancer Institute, Boston, MA 02115, USA.

Abstract

The fusion between echinoderm microtubule-associated protein-like 4 (EML4) and anaplastic lymphoma kinase (ALK) has recently been identified in a subset of non-small cell lung cancers (NSCLCs). EML4-ALK is most often detected in never smokers with lung cancer and has unique pathologic features. EML4-ALK is oncogenic both in vitro and in vivo and ALK kinase inhibitors are quite effective in pre-clinical model systems. More recently ALK inhibitors have entered clinical development and remarkably clinical efficacy has been observed in NSCLC patients harbouring EML4-ALK translocations. This review will focus on the biology, clinical characteristics, diagnosis and treatment of EML4-ALK NSCLC.

PMID:: 20418096; [PubMed - indexed for MEDLINE]
PMCID:: PMC2888755

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Cited by 10 PubMed Central articles

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