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J Neuroimmunol. 2010 Jun;223(1-2):13-9. doi: 10.1016/j.jneuroim.2010.03.018. Epub 2010 Apr 22.

Endogenous type-I interferon activity is not associated with depression or fatigue in systemic lupus erythematosus.

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  • 1Division of Rheumatology & Clinical Immunology, University of Florida, Gainesville, FL 32610-0221, USA.


Patients with systemic lupus erythematosus (SLE) often suffer from depression and fatigue in addition to the physical manifestations of the autoimmune disease. Elevated production of type-I interferons (IFN-I) has been found in lupus patients and IFN-I can precipitate a variety of neuropsychiatric side effects. This study was conducted to evaluate the relationship between dysregulated IFN-I production and the presence of depression or fatigue in lupus patients. Through cross-sectional and longitudinal analysis we found no significant correlation between abnormal IFN-I levels (as measured by peripheral blood expression of IFN-I-stimulated genes) and neuropsychiatric manifestations. Elevation of endogenous serum IFN-I levels is unlikely to account for the depression and fatigue associated with SLE.

Copyright 2010. Published by Elsevier B.V. All rights reserved.

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