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J Autism Dev Disord. 2011 Jan;41(1):122-9. doi: 10.1007/s10803-010-1019-6.

Brief report: a preliminary study of fetal head circumference growth in autism spectrum disorder.

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  • 1Telethon Institute for Child Health Research, Centre for Child Health Research, University of Western Australia, 100 Roberts Road, Subiaco, Perth, WA, 6008, Australia. awhitehouse@ichr.uwa.edu.au

Abstract

Fetal head circumference (HC) growth was examined prospectively in children with autism spectrum disorder (ASD). ASD participants (N = 14) were each matched with four control participants (N = 56) on a range of parameters known to influence fetal growth. HC was measured using ultrasonography at approximately 18 weeks gestation and again at birth using a paper tape-measure. Overall body size was indexed by fetal femur-length and birth length. There was no between-groups difference in head circumference at either time-point. While a small number of children with ASD had disproportionately large head circumference relative to body size at both time-points, the between-groups difference did not reach statistical significance in this small sample. These preliminary findings suggest that further investigation of fetal growth in ASD is warranted.

PMID:
20414801
[PubMed - indexed for MEDLINE]
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