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Nat Rev Immunol. 2010 May;10(5):317-27. doi: 10.1038/nri2744.

Monoclonal antibodies: versatile platforms for cancer immunotherapy.

Author information

  • 1Lombardi Comprehensive Cancer Center, Georgetown University Medical Center, Washington, DC 20057, USA. weinerl@georgetown.edu

Abstract

Antibodies are important therapeutic agents for cancer. Recently, it has become clear that antibodies possess several clinically relevant mechanisms of action. Many clinically useful antibodies can manipulate tumour-related signalling. In addition, antibodies exhibit various immunomodulatory properties and, by directly activating or inhibiting molecules of the immune system, antibodies can promote the induction of antitumour immune responses. These immunomodulatory properties can form the basis for new cancer treatment strategies.

PMID:
20414205
[PubMed - indexed for MEDLINE]
PMCID:
PMC3508064
Free PMC Article

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