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J Alzheimers Dis. 2010;21(1):75-9. doi: 10.3233/JAD-2010-091603.

MiR-107 is reduced in Alzheimer's disease brain neocortex: validation study.

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  • 1Department of Pathology and Division of Neuropathology, University of Kentucky Medical Center and Sanders-Brown Center on Aging, University of Kentucky, Lexington, KY 40536-0230, USA. pnels2@email.uky.edu

Abstract

MiR-107 is a microRNA (miRNA) that we reported previously to have decreased expression in the temporal cortical gray matter early in the progression of Alzheimer's disease (AD). Here we study a new group of well-characterized human temporal cortex samples (N=19). MiR-107 expression was assessed, normalized to miR-124 and let-7a. Correlation was observed between decreased miR-107 expression and increased neuritic plaque counts (P< 0.05) and neurofibrillary tangle counts (P< 0.02) in adjacent brain tissue. Adjusted miR-107 and BACE1 mRNA levels tended to correlate negatively (trend with regression P< 0.07). In sum, miR-107 expression tends to be lower relative to other miRNAs as AD progresses.

PMID:
20413881
[PubMed - indexed for MEDLINE]
PMCID:
PMC2910235
Free PMC Article

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