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Radiat Prot Dosimetry. 2010 Jul;140(2):103-36. doi: 10.1093/rpd/ncq141. Epub 2010 Apr 22.

Review and evaluation of updated research on the health effects associated with low-dose ionising radiation.

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  • 1Department of Medical Physics, Memorial Sloan-Kettering Cancer Center, New York, NY 10021, USA. dauerl@mskcc.org

Abstract

While radiation health risks at low doses have traditionally been estimated from high-dose studies, we have reviewed recent literature and concluded that the mechanisms of action for many biological endpoints may be different at low doses from those observed at high doses; that acute doses <100 mSv may be too small to allow epidemiological detection of excess cancers given the background of naturally occurring cancers; that low-dose radiation research should use holistic approaches such as systems-based methods to develop models that define the shape of the dose-response relationship; and that these results should be combined with the latest epidemiology to produce a comprehensive understanding of radiation effects that addresses both damage, likely with a linear effect, and response, possibly with non-linear consequences. Continued research is needed to understand how radiobiology and epidemiology advances should be used to effectively model radiation worker risks.

PMID:
20413418
[PubMed - indexed for MEDLINE]
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