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    FEBS Lett. 2010 Jun 3;584(11):2403-8. Epub 2010 Apr 20.

    Mechanisms involved in the enhancement of mammalian target of rapamycin signalling and hypertrophy in skeletal muscle of myostatin-deficient mice.

    Lipina C, Kendall H, McPherron AC, Taylor PM, Hundal HS.

    Source

    Division of Molecular Physiology, Sir James Black Centre, College of Life Sciences, University of Dundee, Dundee, United Kingdom.

    Abstract

    Myostatin deficiency leads to both an increased rate of protein synthesis and skeletal muscle hypertrophy. However, the mechanisms involved in mediating these effects are not yet fully understood. Here, we demonstrate that genetic loss of myostatin leads to enhanced muscle expression of both protein kinase B and mammalian target of rapamycin/S6K signalling components, consistent with their elevated activity. This is associated with a reduction in the expression of PGC1alpha and COX IV, proteins which play important roles in maintaining mitochondrial function. Furthermore, we show that these changes in signalling and protein expression are largely independent of alterations in intramuscular amino acid content. Our findings, therefore, reveal potential new mechanisms and further contribute to our understanding of myostatin-regulated skeletal muscle growth and function.

    Copyright 2010 Federation of European Biochemical Societies. All rights reserved.

    PMID:
    20412806
    [PubMed - indexed for MEDLINE]
    PMCID: PMC2874630
    Free PMC Article

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        Elkina Y, von Haehling S, Anker SD, Springer J. J Cachexia Sarcopenia Muscle. 2011 Sep; 2(3):143-151. Epub 2011 Jul 26.

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