Send to:

Choose Destination
See comment in PubMed Commons below
Curr Opin Pharmacol. 2010 Jun;10(3):218-25. doi: 10.1016/j.coph.2010.03.004. Epub 2010 Apr 19.

Overview of asthma; the place of the T cell.

Author information

  • 1Meakins-Christie Laboratories, Department of Medicine, McGill University, 3626 St. Urbain, Montreal, Quebec H2X 2P2, Canada.


Asthma is an inflammatory disease which is associated with activated T cells in the airway wall. The contribution of the T lymphocyte to inflammation in asthma has been extensively studied through descriptions of T cell subsets in the airway wall of asthmatic patients and from animal and cellular models. Allergy-driven airway disease is mediated primarily by the T helper (Th)2 cell subset. Other subsets, such as Th1, Th17, invariant natural killer T and CD8+ T cells likely contribute to the development, and possibly the progression of established disease. Resolution of inflammation is controlled in part by regulatory T cells. Therapies directed at T cells and their cytokines have been disappointing in asthma despite, in some instances, promising results on allergen challenge. This suggests that the induction of asthma may be T-cell-mediated and allergen-triggered, whereas disease may be sustained and exacerbated by other mechanisms.

Copyright 2010 Elsevier Ltd. All rights reserved.

[PubMed - indexed for MEDLINE]
PubMed Commons home

PubMed Commons

How to join PubMed Commons

    Supplemental Content

    Full text links

    Icon for Elsevier Science
    Loading ...
    Write to the Help Desk