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Cancer Res. 2010 May 15;70(10):3857-60. doi: 10.1158/0008-5472.CAN-10-0163. Epub 2010 Apr 20.

Receptor tyrosine kinase coactivation networks in cancer.

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  • 1Department of Biological Engineering, Massachusetts Institute of Technology, Cambridge, Massachusetts, USA.


Cancer cells employ multiple mechanisms to evade tightly regulated cellular processes such as proliferation, apoptosis, and senescence. Systems-wide analyses of tumors have recently identified receptor tyrosine kinase (RTK) coactivation as an important mechanism by which cancer cells achieve chemoresistance. This mini-review discusses our current understanding of the complex and dynamic process of RTK coactivation. We highlight how systems biology and computational modeling have been employed to predict integrated signaling outcomes and cancer phenotypes downstream of RTK coactivation. We conclude by providing an outlook on the feasibility of targeting RTK networks to overcome chemoresistance in cancer.

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