Display Settings:

Format

Send to:

Choose Destination
See comment in PubMed Commons below
Cardiovasc Ther. 2011 Apr;29(2):125-39. doi: 10.1111/j.1755-5922.2009.00131.x.

The role of endothelial progenitor cells in vascular repair after arterial injury and atherosclerotic plaque development.

Author information

  • 1First Cardiology Unit, Hippokration Hospital, Athens University Medical School, Athens, Greece Department of Cardiology, University of Athens, Athens, Greece.

Abstract

Endothelial progenitor cells (EPCs) are under investigation due to their association with vascular injury. In response to chemotactic stimuli they are mobilized from bone-marrow and nonbone marrow sites, they migrate, adhere and home to the injured vessel. Numerous molecular and cellular pathways participate and converge to the EPCs mediated vascular repair. However, the exact phenotypic properties, modes of functions and effects in vascular diseases and particularly in atherosclerosis are under investigation. EPCs represent a heterogeneous group of cells in different stages of differentiation, from hematopoietic bone marrow progenitors to mature endothelial cells that participate in adult vascular repair under ischemic or apoptotic stimuli. This review aims to provide an integrative view of EPC-mediated vascular repair.

© 2010 Blackwell Publishing Ltd.

KEYWORDS:

Atherosclerosis; Endothelial progenitors; Neoangiogenesis

PMID:
20406237
[PubMed - in process]
PubMed Commons home

PubMed Commons

0 comments
How to join PubMed Commons

    Supplemental Content

    Icon for Blackwell Publishing
    Loading ...
    Write to the Help Desk