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Semin Cell Dev Biol. 2010 Sep;21(7):699-711. doi: 10.1016/j.semcdb.2010.04.003. Epub 2010 Apr 18.

Autophagy and innate immunity: triggering, targeting and tuning.

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  • 1Department of Internal Medicine, University of Texas Southwestern Medical Center, Dallas, TX 75390, USA.

Abstract

Autophagy is a conserved catabolic stress response pathway that is increasingly recognized as an important component of both innate and acquired immunity to pathogens. The activation of autophagy during infection not only provides cell-autonomous protection through lysosomal degradation of invading pathogens (xenophagy), but also regulates signaling by other innate immune pathways. This review will focus on recent advances in our understanding of three major areas of the interrelationship between autophagy and innate immunity, including how autophagy is triggered during infection, how invading pathogens are targeted to autophagosomes, and how the autophagy pathway participates in "tuning" the innate immune response.

(c) 2010 Elsevier Ltd. All rights reserved.

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