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    FEBS Lett. 2010 Jun 3;584(11):2237-41. Epub 2010 Apr 20.

    The domain structure of talin: residues 1815-1973 form a five-helix bundle containing a cryptic vinculin-binding site.

    Goult BT, Gingras AR, Bate N, Barsukov IL, Critchley DR, Roberts GC.

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    Department of Biochemistry, University of Leicester, Leicester, UK.

    Abstract

    Talin is a large flexible rod-shaped protein that activates the integrin family of cell adhesion molecules and couples them to cytoskeletal actin. Its rod region consists of a series of helical bundles. Here we show that residues 1815-1973 form a 5-helix bundle, with a topology unique to talin which is optimally suited for formation of a long rod such as talin. This is much more stable than the 4-helix (1843-1973) domain described earlier and as a result its vinculin binding sequence is inaccessible to vinculin at room temperature, with implications for the overall mechanism of the talin-vinculin interaction.

    Copyright 2010 Federation of European Biochemical Societies. Published by Elsevier B.V. All rights reserved.

    PMID:
    20399778
    [PubMed - indexed for MEDLINE]
    PMCID:
    PMC2887493
    Free PMC Article

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