Format

Send to:

Choose Destination
See comment in PubMed Commons below
Brain Res. 2010 Sep 2;1350:2-9. doi: 10.1016/j.brainres.2010.04.011. Epub 2010 Apr 24.

Neurodevelopmental actions of leptin.

Author information

  • 1The Saban Research Institute, Neuroscience Program, Childrens Hospital Los Angeles, University of Southern California, Los Angeles, CA 90027, USA. sbouret@chla.usc.edu

Abstract

Leptin is well known as an important hormone in the central control of feeding behavior. During development, fetuses and newborns are exposed to leptin and recent evidence has shown that leptin receptors are widespread throughout the developing brain. Accordingly, leptin affects brain development during both pre- and postnatal life. The actions of leptin in the developing brain are generally permanent and range from the establishment of hypothalamic circuits to plasticity in cortical pathways. The cellular events mediated by leptin include the following: neurogenesis, axon growth, and synaptogenesis. Nutritional manipulation of leptin secretion during perinatal life has generated considerable concern, and the developing brain appears to be a particularly sensitive target for these environmental changes.

2010 Elsevier B.V. All rights reserved.

PMID:
20399755
[PubMed - indexed for MEDLINE]
PMCID:
PMC3654158
Free PMC Article
PubMed Commons home

PubMed Commons

0 comments
How to join PubMed Commons

    Supplemental Content

    Full text links

    Icon for Elsevier Science Icon for PubMed Central
    Loading ...
    Write to the Help Desk