My NCBISign In

Display Settings:

Format

Send to:

Choose Destination
    J Clin Neurosci. 2010 Jul;17(7):874-8.

    Correlation between muscle atrophy on MRI and manual strength testing in hereditary neuropathies.

    del Porto LA, Nicholson GA, Ketheswaren P.

    Source

    Department of Molecular Genetics, Concord Repatriation General Hospital, Concord, New South Wales, Australia. ldel0178@gmp.usyd.edu.au

    Abstract

    MRI shows areas where muscle has been replaced by fat, a process which occurs in neuropathies. The purpose of this study was to investigate the usefulness of MRI in assessing disease severity in Charcot-Marie-Tooth (CMT) and hereditary motor neuropathy (HMN) compared to manual muscle testing (MMT). MRI and MMT correlated well (Spearman's rank correlation coefficient 0.910, 0.789-1.0). MRI was useful to document the extent and pattern of muscle atrophy and fat replacement and to determine the level of denervation. In addition, nerve length dependent denervation was confirmed in both CMT and HMN. MRI will be useful to confirm MMT findings and may be helpful for diagnosis of early or subclinical disease, as well as to further investigate the mechanisms of hereditary neuropathies.

    PMID:
    20399669
    [PubMed - indexed for MEDLINE]

    Publication Types, MeSH Terms

    Publication Types

    MeSH Terms

    LinkOut - more resources

    Full Text Sources

    Medical

      Supplemental Content

      Click here to read

      Related citations

      See reviews... See all...

      Recent activity

      Clear Turn Off Turn On

      Your browsing activity is empty.

      Activity recording is turned off.

      Turn recording back on

      See more...
      You are here: NCBI > Literature > PubMed
      Write to the Help Desk