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Trends Cell Biol. 2010 Jun;20(6):319-28. doi: 10.1016/j.tcb.2010.03.005.

Keeping in touch with contact inhibition of locomotion.

Author information

  • 1Department of Cell and Developmental Biology, University College London, Gower Street, London WC1E 6BT, UK. r.mayor@ucl.ac.uk

Abstract

Contact inhibition of locomotion (CIL) is the process by which cells in vitro change their direction of migration upon contact with another cell. Here, we revisit the concept that CIL plays a central role in the migration of single cells and in collective migration, during both health and disease. Importantly, malignant cells exhibit a diminished CIL behaviour which allows them to invade healthy tissues. Accumulating evidence indicates that CIL occurs in vivo and that regulation of small Rho GTPases is important in the collapse of cell protrusions upon cell contact, the first step of CIL. Finally, we propose possible cell surface proteins that could be involved in the initial contact that regulates Rho GTPases during CIL.

(c) 2010 Elsevier Ltd. All rights reserved.

PMID:
20399659
[PubMed - indexed for MEDLINE]
PMCID:
PMC2927909
Free PMC Article

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