Display Settings:

Format

Send to:

Choose Destination
See comment in PubMed Commons below
Science. 2010 May 14;328(5980):916-9. doi: 10.1126/science.1186366. Epub 2010 Apr 15.

Genome-wide evolutionary analysis of eukaryotic DNA methylation.

Author information

  • 1Department of Plant and Microbial Biology, 211 Koshland Hall, University of California, Berkeley, CA 94720, USA.

Abstract

Eukaryotic cytosine methylation represses transcription but also occurs in the bodies of active genes, and the extent of methylation biology conservation is unclear. We quantified DNA methylation in 17 eukaryotic genomes and found that gene body methylation is conserved between plants and animals, whereas selective methylation of transposons is not. We show that methylation of plant transposons in the CHG context extends to green algae and that exclusion of histone H2A.Z from methylated DNA is conserved between plants and animals, and we present evidence for RNA-directed DNA methylation of fungal genes. Our data demonstrate that extant DNA methylation systems are mosaics of conserved and derived features, and indicate that gene body methylation is an ancient property of eukaryotic genomes.

Comment in

PMID:
20395474
[PubMed - indexed for MEDLINE]
Free full text
PubMed Commons home

PubMed Commons

0 comments
How to join PubMed Commons

    Supplemental Content

    Full text links

    Icon for HighWire Icon for Faculty of 1000
    Loading ...
    Write to the Help Desk