Format

Send to:

Choose Destination
See comment in PubMed Commons below
Pharmacol Ther. 2010 Jun;126(3):244-50. doi: 10.1016/j.pharmthera.2010.03.004. Epub 2010 Apr 13.

Identification and biological significance of G protein-coupled receptor associated sorting proteins (GASPs).

Author information

  • 1Institut de Recherche de l'ESBS, CNRS - Université de Strasbourg, FRE3211, Bld Sébastien Brant, 67412 Illkirch, France.

Erratum in

  • Pharmacol Ther. 2011 Oct;132(1):123.

Abstract

G protein-coupled receptors (GPCRs) represent one of the most abundant protein families encoded by the human genome. They are involved in the modulation of numerous physiological functions and represent major drug targets. Their activity is tightly controlled by a vast array of interacting partners that modulate their membrane targeting, intracellular trafficking and signalling properties. Among them, several proteins from the same family, G protein-coupled receptor associated sorting proteins (GASP), have been shown to display a broad spectrum of interactions with GPCRs. In addition to their postulated role in the modulation of the post-endocytic sorting of these receptors, recent data indicate that several GASPs may modulate the transcriptional activity of the cell through their interaction with transcription factors. However, no clear molecular function has been assigned yet to this protein family. In this review, we describe the discovery of GASPs, their major features, interacting partners, functions and possible involvement in pathological situations including neurodegenerative diseases and cancer.

Copyright 2010 Elsevier Inc. All rights reserved.

PMID:
20394773
[PubMed - indexed for MEDLINE]
PubMed Commons home

PubMed Commons

0 comments
How to join PubMed Commons

    Supplemental Content

    Full text links

    Icon for Elsevier Science
    Loading ...
    Write to the Help Desk