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FEBS Lett. 2010 Jun 18;584(12):2646-51. doi: 10.1016/j.febslet.2010.04.005. Epub 2010 Apr 13.

Arf GAPs: gatekeepers of vesicle generation.

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  • 1University of Basel, Growth and Development, Biozentrum, Switzerland. anne.spang@unibas.ch


Arf GAP proteins are a versatile and diverse group of proteins. They control the activity of the GTP-binding proteins of the ARF family by inducing the hydrolysis of GTP that is bound to Arf proteins. The best-studied role of Arf GAPs is in intracellular traffic. In this review, we will focus mainly on the Arf GAPs that play a role in vesicle formation, Arf GAP1, Arf GAP2 and Arf GAP3 and their yeast homologues, Gcs1p and Glo3p. We discuss the roles of Arf GAPs as regulators and effectors for Arf GTP-binding proteins.

Copyright 2010 Federation of European Biochemical Societies. All rights reserved.

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