Display Settings:

Format

Send to:

Choose Destination
See comment in PubMed Commons below
Physiol Rev. 2010 Apr;90(2):419-63. doi: 10.1152/physrev.00037.2009.

Plastic synaptic networks of the amygdala for the acquisition, expression, and extinction of conditioned fear.

Author information

  • 1Institute of Physiology, Westfaelische Wilhelms-University, Muenster, Germany; and Rutgers State University, Newark, New Jersey, USA. papechris@ukmuenster.de

Erratum in

  • Physiol Rev. 2010 Jul;90(3):1269.

Abstract

The last 10 years have witnessed a surge of interest for the mechanisms underlying the acquisition and extinction of classically conditioned fear responses. In part, this results from the realization that abnormalities in fear learning mechanisms likely participate in the development and/or maintenance of human anxiety disorders. The simplicity and robustness of this learning paradigm, coupled with the fact that the underlying circuitry is evolutionarily well conserved, make it an ideal model to study the basic biology of memory and identify genetic factors and neuronal systems that regulate the normal and pathological expressions of learned fear. Critical advances have been made in determining how modified neuronal functions upon fear acquisition become stabilized during fear memory consolidation and how these processes are controlled in the course of fear memory extinction. With these advances came the realization that activity in remote neuronal networks must be coordinated for these events to take place. In this paper, we review these mechanisms of coordinated network activity and the molecular cascades leading to enduring fear memory, and allowing for their extinction. We will focus on Pavlovian fear conditioning as a model and the amygdala as a key component for the acquisition and extinction of fear responses.

PMID:
20393190
[PubMed - indexed for MEDLINE]
PMCID:
PMC2856122
Free PMC Article
PubMed Commons home

PubMed Commons

0 comments
How to join PubMed Commons

    Supplemental Content

    Full text links

    Icon for HighWire Icon for PubMed Central
    Loading ...
    Write to the Help Desk