Blood. 2010 Jun 24;115(25):5137-46. doi: 10.1182/blood-2010-01-266007. Epub 2010 Apr 14.
Risk-adapted treatment of acute promyelocytic leukemia based on all-trans retinoic acid and anthracycline with addition of cytarabine in consolidation therapy for high-risk patients: further improvements in treatment outcome.
Sanz MA,
Montesinos P,
Rayón C,
Holowiecka A,
de la Serna J,
Milone G,
de Lisa E,
Brunet S,
Rubio V,
Ribera JM,
Rivas C,
Krsnik I,
Bergua J,
González J,
Díaz-Mediavilla J,
Rojas R,
Manso F,
Ossenkoppele G,
González JD,
Lowenberg B;
PETHEMA and HOVON Groups.
de Heredia JM, Hernández JM, Arias J, Ramos F, Román A, de la Serna J, Negri S, Rayón C, Esteve J, Fernández-Calvo FJ, Díaz-Mediavilla J, Gil C, Pérez-encinas M, Tormo M, Olave M, Amutio E, Pedro C, Gorosquieta A, Viguria M, Zudaire M, Molero T, Sayas MJ, Guardia R, Manso F, Rivas C, Esquembre C, García R, Alcalá A, López JA, Rubio V, Amigo ML, Linares M, Ribera JM, San Miguel JD, Debén G, Escoda L, de la Cámara R, Molines A, Loureiro C, Allegue MJ, Amador L, Martí JM, Madero L, Lassaletta A, Cabezudo M, García-Laraña J, Rojas R, Ortega F, Peñarrubia MJ, Puente F, López-Ibor B, Brunet S, Bergua JM, Ibáñez J, Sánchez P, Novo A, Font LL, Guinea JM, Montero A, González M, Sanz MA, Martín G, Martínez J, Montesinos P, Verdeguer A, García P, Conde E, García J, Capote FJ, Krsnik I, Bueno J, Bastida P, Rubio A, Fuster JL, González J, Pérez I, Molina J, Mateos MC, Ardaiz MA, Rodríguez-Calvillo M, Poderós C, Arnán M, Duarte R, Hernández JA, Díaz-Morfa M, Martín-Chacón E, Calvo-Villas JM, García-Belmonte D, Hernández-Maraver D, Ossenkoppele GJ, van der Lelie J, Lowenberg B, Sonneveld P, Zijlmans M, Vellenga E, Maertens J, de Valk B, Wijermans PW, de Groot MR, Schouten HC, Biesma DH, van Marwijk Kooy M, de Lisa E.
Source
Hospital Universitario La Fe, Valencia, Spain. msanz@uv.es
Abstract
A risk-adapted strategy based on all-trans retinoic acid (ATRA) and anthracycline monochemotherapy (PETHEMA LPA99 trial) has demonstrated a high antileukemic efficacy in acute promyelocytic leukemia. We designed a new trial (LPA2005) with the objective of achieving stepwise improvements in outcome. Between July 2005 and April 2009, low- and intermediate-risk patients (leukocytes < 10 x 10(9)/L) received a reduced dose of mitoxantrone for the second consolidation course, whereas high- risk patients younger than 60 years of age received cytarabine combined with ATRA and idarubicin in the first and third consolidation courses. Of 372 patients attaining complete remission after ATRA plus idarubicin (92.5%), 368 proceeded to consolidation therapy. For low- and intermediate-risk patients, duration of neutropenia and thrombocytopenia and hospital stay were significantly reduced without sacrificing antileukemic efficacy, compared with the previous LPA99 trial. For high-risk patients, the 3-year relapse rate was significantly lower in the LPA2005 trial (11%) than in the LPA99 (26%; P = .03). Overall disease-free survival was also better in the LPA2005 trial (P = .04). In conclusion, the lower dose of mitoxantrone resulted in a significant reduction of toxicity and hospital stay while maintaining the antileukemic activity, and the combination of ATRA, idarubicin, and cytarabine for high-risk acute promyelocytic leukemia significantly reduced the relapse rate in this setting. Registered at http://www.clinicaltrials.gov as NCT00408278.
- PMID:
- 20393132
- [PubMed - indexed for MEDLINE]
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