This study examined relationships between emotional adjustment and a number of coping styles and strategies in people with cancer. Two-hundred eighty-three adults completed measures of positive and negative emotions, subjective ratings of cancer-related symptoms and functional impairment, coping strategies, hope, benefit finding, emotional approach/avoidance, and cancer-related social support. Among the coping strategies, self-blame and behavioral disengagement were consistently associated with poor adjustment, while acceptance and humor were consistently associated with good adjustment. Among the broader measures of coping style, there were associations between poor adjustment and emotional processing, and between good adjustment and hope, benefit finding, and cancer-related social support.