Display Settings:

Format

Send to:

Choose Destination
See comment in PubMed Commons below
Br J Cancer. 2010 Apr 27;102(9):1422-7. doi: 10.1038/sj.bjc.6605658. Epub 2010 Apr 13.

Predicted vitamin D status and pancreatic cancer risk in two prospective cohort studies.

Author information

  • 1Channing Laboratory, Department of Medicine, Brigham and Women's Hospital, Harvard Medical School, 181 Longwood Avenue, Boston, MA 02115, USA. ying.bao@channing.harvard.edu

Abstract

BACKGROUND:

Studies evaluating vitamin D status in relation to pancreatic cancer risk have yielded inconsistent results.

METHODS:

We prospectively followed 118 597 participants in the Nurses' Health Study and Health Professionals Follow-up Study from 1986 to 2006. We calculated a 25-hydroxyvitamin D (25(OH)D) score from known predictors of vitamin D status for each individual and then examined the predicted 25(OH)D levels in relation to pancreatic cancer risk. Relative risks (RRs) and 95% confidence intervals (95% CIs) were estimated using Cox proportional hazards models adjusted for age, sex, race, height, smoking, and diabetes. We then further adjusted for body mass index (BMI) and physical activity in a sensitivity analysis.

RESULTS:

During 20 years of follow-up, we identified 575 incident pancreatic cancer cases. Higher 25(OH)D score was associated with a significant reduction in pancreatic cancer risk; compared with the lowest quintile, participants in the highest quintile of 25(OH)D score had an adjusted RR of 0.65 (95% CI=0.50-0.86; P(trend)=0.001). Results were similar when we further adjusted for BMI and physical activity.

CONCLUSIONS:

Higher 25(OH)D score was associated with a lower risk of pancreatic cancer in these two prospective cohort studies.

PMID:
20389298
[PubMed - indexed for MEDLINE]
PMCID:
PMC2865766
Free PMC Article
PubMed Commons home

PubMed Commons

0 comments
How to join PubMed Commons

    Supplemental Content

    Icon for Nature Publishing Group Icon for PubMed Central
    Loading ...
    Write to the Help Desk