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Acta Psychiatr Scand. 2010 Dec;122(6):454-60. doi: 10.1111/j.1600-0447.2010.01561.x.

Antidepressant medication prevents suicide in depression.

Author information

  • 1Department of Clinical Neuroscience, Karolinska Institute, Stockholm, Sweden. goran.isacsson@ki.se

Abstract

OBJECTIVE:

Ecological studies have demonstrated a substantial decrease in suicide in parallel with an increasing use of antidepressants. To investigate on the individual level the hypothesis that antidepressant medication was a causal factor.

METHOD:

Data on the toxicological detection of antidepressants in 18 922 suicides in Sweden 1992-2003 were linked to registers of psychiatric hospitalization as well as registers with sociodemographic data.

RESULTS:

The probability for the toxicological detection of an antidepressant was lowest in the non-suicide controls, higher in suicides, and even higher in suicides that had been psychiatric in-patients but excluding those who had been in-patients for the treatment of depression.

CONCLUSION:

The finding that in-patient care for depression did not increase the probability of the detection of antidepressants in suicides is difficult to explain other than by the assumption that a substantial number of depressed individuals were saved from suicide by postdischarge treatment with antidepressant medication.

© 2010 John Wiley & Sons A/S.

PMID:
20384599
[PubMed - indexed for MEDLINE]
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