Expert Rev Pharmacoecon Outcomes Res. 2010 Apr;10(2):163-75.

Patient outcomes after anti TNF-alpha drugs for Crohn's disease.

Assasi N, Blackhouse G, Xie F, Marshall JK, Irvine EJ, Gaebel K, Robertson D, Campbell K, Hopkins R, Goeree R.

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Programs for Assessment of Technology in Health Research Institute, St Joseph's Healthcare, Hamilton, 25 Main Street West, Suite 2000 ON, Canada. assasin@mcmaster.ca

Abstract

Crohn's disease (CD) is a chronic inflammatory bowel disease with a relatively high prevalence rate in North America. More than 50% of CD patients require surgery at some stage of their disease. Anti-TNF-alpha drugs are increasingly being used in patients with CD who have had an inadequate response to conventional therapy. Treatment with anti-TNF-alpha agents aims at improving symptom control and reducing the need for hospitalization and surgery. This review examines the clinical effectiveness of three anti-TNF-alpha agents (infliximab, adalimumab and etanercept) in moderate and severe CD. The review further considers the evidence for the harms and benefits associated with switching from one anti-TNF-alpha agent to another and strategies to optimize the timing of therapy.

PMID:: 20384563; [PubMed - indexed for MEDLINE]

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Patient outcomes after anti TNF-alpha drugs for Crohn's disease.

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