Format

Send to:

Choose Destination
See comment in PubMed Commons below
Neurosci Lett. 2010 May 31;476(2):70-3. doi: 10.1016/j.neulet.2010.04.005. Epub 2010 Apr 9.

Novel nootropic dipeptide Noopept increases inhibitory synaptic transmission in CA1 pyramidal cells.

Author information

  • 1Department of Brain Research, Scientific Center of Neurology, Russian Academy of Medical Sciences, by-str. Obukha 5, Moscow 105064, Russia.

Abstract

Effects of newly synthesized nootropic and anxiolytic dipeptide Noopept on inhibitory synaptic transmission in hippocampal CA1 pyramidal cells were investigated using patch-clamp technique in whole-cell configuration. Bath application of Noopept (1 microM) significantly increased the frequency of spike-dependant spontaneous IPSCs whereas spike-independent mIPSCs remained unchanged. It was suggested that Noopept mediates its effect due to the activation of inhibitory interneurons terminating on CA1 pyramidal cells. Results of current clamp recording of inhibitory interneurons residing in stratum radiatum confirmed this suggestion.

Copyright 2010 Elsevier Ireland Ltd. All rights reserved.

PMID:
20382202
[PubMed - indexed for MEDLINE]
PubMed Commons home

PubMed Commons

0 comments
How to join PubMed Commons

    Supplemental Content

    Full text links

    Icon for Elsevier Science
    Loading ...
    Write to the Help Desk