Format

Send to

Choose Destination
See comment in PubMed Commons below
Trends Endocrinol Metab. 2010 Jul;21(7):441-8. doi: 10.1016/j.tem.2010.02.008. Epub 2010 Apr 8.

Emerging roles for the TGFbeta family in pancreatic beta-cell homeostasis.

Author information

  • 1Pioneer Valley Life Science Institute, University of Massachusetts Amherst, Springfield, MA 01107, USA.

Abstract

Loss of functional beta-cells is the primary cause of type 2 diabetes, so that there is an acute need to understand how beta-cell number and function are regulated in the adult under normal physiological conditions. Recent studies suggest that members of the transforming growth factor (TGF)-beta family regulate beta-cell function and glucose homeostasis. These factors are also likely to influence beta-cell proliferation and/or the incorporation of new beta-cells from progenitors in adults. Soluble TGFbeta antagonists also appear to have important roles in maintaining homeostasis, and the coordinated activity of TGFbeta family members is likely to regulate the differentiation and function of adult beta-cells, raising the possibility of developing new diabetes therapies based on TGFbeta agonists or antagonists.

Copyright 2010 Elsevier Ltd. All rights reserved.

[PubMed - indexed for MEDLINE]
Free PMC Article
PubMed Commons home

PubMed Commons

0 comments
How to join PubMed Commons

    Supplemental Content

    Full text links

    Icon for Elsevier Science Icon for PubMed Central
    Loading ...
    Write to the Help Desk