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Clin Immunol. 2010 Jul;136(1):105-15. doi: 10.1016/j.clim.2010.03.003. Epub 2010 Apr 8.

B cells require "nurturing" by CD4 T cells during development in order to respond in chronic graft-versus-host model of systemic lupus erythematosus.

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  • 1Division of Rheumatology, University of Pennsylvania, Philadelphia, PA 19104, USA.

Abstract

The murine chronic GVH (cGVH) model of SLE is induced by allo-recognition of foreign major histocompatibility complex (MHC) class II determinants. Previous studies have shown that syngeneic CD4(+) T cells are needed during B cell development in order to induce cGVH response in CD4KO mice. Our present studies show that B cells require "nurturing" by CD4 T cells through much of their ontogeny in order to respond to allo-signaling and become autoreactive. The nurturing process does not require antigen-specific cognate interactions between CD4 T cells and B cells. It is mediated by IL-4, but not IL-10, IL-6 and IFN-gamma. The CD4 T cell nurturing may be supplanted by large doses of IL-4 and/or by agonistic anti-CD40 mAb. Understanding the mechanism of this "nurturing" process may yield clues to the role of CD4 T cells in lupus and in host defense in general.

(c) 2010 Elsevier Inc. All rights reserved.

PMID:
20381429
[PubMed - indexed for MEDLINE]
PMCID:
PMC2891082
Free PMC Article

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