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Mod Rheumatol. 2010 Aug;20(4):405-9. doi: 10.1007/s10165-010-0289-3. Epub 2010 Apr 8.

Two cases of late-onset drug-induced lupus erythematosus caused by ticlopidine in elderly men.

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  • 1Department of Rheumatology and Clinical Immunology, Graduate School of Medicine, Kyoto University, Kyoto, Japan.


We have experienced two cases of drug-induced lupus erythematosus caused by ticlopidine in the last three years. Both were late-onset cases (1 and 4 years) that occurred in elderly men (76 and 81 years old). The common features were fever, arthralgia, myalgia, serositis, and the presence of anti-histone autoantibodies. Because ticlopidine is widely used in elderly people with ischemic vascular disease, ticlopidine-induced lupus should be considered when patients taking ticlopidine present lupus-like symptoms.

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