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Clin Microbiol Rev. 2010 Apr;23(2):299-323. doi: 10.1128/CMR.00068-09.

The changing microbial epidemiology in cystic fibrosis.

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  • 1Department of Pediatrics and Communicable Diseases, 1150 W. Medical Center Drive, 8323 MSRB III, SPC 5646, University of Michigan Medical School, Ann Arbor, MI 48109, USA.


Infection of the airways remains the primary cause of morbidity and mortality in persons with cystic fibrosis (CF). This review describes salient features of the epidemiologies of microbial species that are involved in respiratory tract infection in CF. The apparently expanding spectrum of species causing infection in CF and recent changes in the incidences and prevalences of infection due to specific bacterial, fungal, and viral species are described. The challenges inherent in tracking and interpreting rates of infection in this patient population are discussed.

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