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J Clin Endocrinol Metab. 2010 Jun;95(6):2868-76. doi: 10.1210/jc.2009-1993. Epub 2010 Apr 6.

Inflammatory markers are increased in youth with type 1 diabetes: the SEARCH Case-Control study.

Author information

  • 1Barbara Davis Center for Childhood Diabetes, University of Colorado Denver, P.O. Box 6511, Mail Stop A-140, Aurora, Colorado 80045, USA. janet.snell-bergeon@ucdenver.edu

Abstract

CONTEXT:

Increased inflammation may contribute to type 1 diabetes (T1D) complications.

OBJECTIVE:

The objective of the study was to investigate the association of inflammation with obesity, hyperglycemia and dyslipidemia in youth with T1D.

DESIGN:

This was a cross-sectional study of youth with and without T1D.

SETTING:

The study was conducted in Colorado and South Carolina.

PATIENTS:

SEARCH Case-Control participants with T1D [n = 553, mean age 15 yr (range 10-22), median duration 2.7 yr] and without diabetes [n = 215, mean age 15 yr (range 10-22)].

INTERVENTION:

This was an observational study.

MAIN OUTCOME MEASURES:

IL-6, high-sensitivity C-reactive protein (hsCRP), fibrinogen, and leptin were measured.

RESULTS:

Inflammatory markers were evaluated by diabetes status, quartiles of glycated hemoglobin, and obesity using multiple linear regression analyses, adjusted for age, sex, study site, race/ethnicity, T1D duration, body mass index, and pubertal status. Compared with controls, youth with T1D had higher IL-6 and fibrinogen levels at all levels of glycemia and obesity, and hsCRP levels were significantly higher in youth with T1D in the top three quartiles of glycated hemoglobin (> or = 7.2%) and among normal-weight subjects. Leptin was lower in youth with poor glycemic control. Higher hsCRP and fibrinogen were correlated with higher total and LDL cholesterol, and apolipoprotein B in youth with T1D, whereas higher fibrinogen was correlated with higher LDL and apolipoprotein B in controls.

CONCLUSIONS:

T1D is characterized by excess inflammation, independent of adiposity and glycemic control. Even T1D youth in good glycemic control had higher levels of IL-6 and fibrinogen than controls. Elevated inflammatory markers were associated with an atherogenic lipid profile, which may contribute to accelerated atherosclerosis in youth with T1D.

PMID:
20371668
[PubMed - indexed for MEDLINE]
PMCID:
PMC2902077
Free PMC Article
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