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Cancer Epidemiol. 2010 Aug;34(4):490-3. doi: 10.1016/j.canep.2010.03.004. Epub 2010 Apr 3.

TYMS, MTHFR, p53 and MDR1 gene polymorphisms in breast cancer patients treated with adjuvant therapy.

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  • 1Clinical Science Department, Universidad de Las Palmas de Gran Canaria, Spain. lhenriquez@dcc.ulpgc.es

Abstract

PURPOSE:

The distribution of TSER (TYMS), C677T (MTHFR), Arg72Pro (p53) and C3435T (MDR1) gene polymorphisms was investigated in 80 consecutive breast cancer patients treated with adjuvant chemotherapy.

RESULTS:

Observed allelic frequencies were: TSER, (2) 0.55 and (3) 0.45; MTHFR C677T, (C) 0.65 and (T) 0.35; p53 Arg72Pro, (Arg) 0.76 and (Pro) 0.24; MDR1 C3435T, (C) 0.51 and (T) 0.49. MTHFR C677T was found to be a strong predictor of the presence of multifocal tumour (odds ratio, 4.1; 95% CI, 1.1-15.7; P=0.035).

CONCLUSION:

Our data indicate that breast cancer patients with the C/C variant may present multifocal tumour most frequently.

PMID:
20371218
[PubMed - indexed for MEDLINE]
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