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Sci Transl Med. 2009 Nov 11;1(6):6ps7. doi: 10.1126/scitranslmed.3000483.

Gut check: testing a role for the intestinal microbiome in human obesity.

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  • 1Department of Medicine, Harvard Medical School, Boston, MA 02115, USA.


By using germ-free mice transplanted with human fecal microbiota, scientists show that a high-fat, high-sugar diet durably changes the transplanted microbiome and that this diet-altered microbiome promotes obesity. This model should encourage investigation of the gut microbiome as a contributor to human metabolic disease and permit discovery of targets for the prevention and treatment of these disorders.

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