Sci Transl Med. 2009 Dec 9;1(10):10ps11.

Parallel paths to predictive biomarkers in oncology: Uncoupling of emergent biomarker development and phase III trial execution.

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Amgen, Thousand Oaks, CA 91320, USA. public@robertsikorski.com

Abstract

It is within pivotal phase III clinical trials that predictive biomarkers have the greatest potential to affect clinical practice by targeting drugs under development to relevant patient subgroups. Predictive biomarkers can be integrated into phase III clinical trials by a variety of approaches, including trial designs that uncouple the processes and actively anticipate the emergence of new biomarkers during trial execution. Here we describe the various approaches in an oncology context.

PMID:: 20368158; [PubMed - indexed for MEDLINE]

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Tumor Markers, Biological

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Parallel paths to predictive biomarkers in oncology: Uncoupling of emergent biom...
Parallel paths to predictive biomarkers in oncology: Uncoupling of emergent biomarker development and phase III trial execution.
Sci Transl Med. 2009 Dec 9 ;1(10):10ps11.

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Parallel paths to predictive biomarkers in oncology: Uncoupling of emergent biomarker development and phase III trial execution.

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