Display Settings:


Send to:

Choose Destination
See comment in PubMed Commons below
Nutrition. 2010 Jun;26(6):585-94. doi: 10.1016/j.nut.2009.10.015. Epub 2010 Apr 3.

Aluminum contamination in products used in parenteral nutrition: has anything changed?

Author information

  • 1Department of Pharmacy, Division of Gastroenterology/Nutrition, Children's Hospital, Boston, Massachusetts, USA. kathleen.gura@childrens.harvard.edu


In July 2004, the U.S. Food and Drug Administration issued a mandate that required manufacturers to include the aluminum content on the labels of the additives commonly used in the compounding of parenteral nutrition solutions. It was the hope that practitioners would use this information to minimize the amount of aluminum exposure provided by parenteral nutrition to less than the 5 mCg/kg/d, the threshold deemed as "safe." Since that time, it has been difficult to easily incorporate these guidelines into clinical practice due to limitations in current product formulations. The purpose of this article is to revisit the rationale for the development of this mandate and to survey the literature since its implementation to determine if any new findings have emerged. A brief overview of aluminum toxicity, the patient populations at risk, treatment options, and compounding considerations is also presented.

Copyright 2010 Elsevier Inc. All rights reserved.

[PubMed - indexed for MEDLINE]
PubMed Commons home

PubMed Commons

How to join PubMed Commons

    Supplemental Content

    Full text links

    Icon for Elsevier Science
    Loading ...
    Write to the Help Desk