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Cell Stem Cell. 2010 Apr 2;6(4):300-8. doi: 10.1016/j.stem.2010.03.003.

Deconstructing pancreas development to reconstruct human islets from pluripotent stem cells.

Author information

  • 1Department of Developmental Biology, Stanford University School of Medicine, Stanford, CA 94305-5329, USA.

Abstract

There is considerable excitement about harnessing the potential of human stem cells to replace pancreatic islets that are destroyed in type 1 diabetes mellitus. However, our current understanding of the mechanisms underlying pancreas and islet ontogeny has come largely from the powerful genetic, developmental, and embryological approaches available in nonhuman organisms. Successful islet reconstruction from human pluripotent cells will require greater attention to "deconstructing" human pancreas and islet developmental biology and consistent application of conditional genetics, lineage tracing, and cell purification to stem cell biology.

Copyright (c) 2010 Elsevier Inc. All rights reserved.

PMID:
20362535
[PubMed - indexed for MEDLINE]
PMCID:
PMC3148083
Free PMC Article

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