Display Settings:

Format

Send to:

Choose Destination
We are sorry, but NCBI web applications do not support your browser and may not function properly. More information
Curr Opin Genet Dev. 2010 Apr;20(2):142-8. doi: 10.1016/j.gde.2010.03.003. Epub 2010 Mar 31.

RNA traffic control of chromatin complexes.

Author information

  • 1BIDMC Department of Pathology, Harvard Medical School, Boston, MA 02215, United States.

Abstract

It is widely accepted that the genome is regulated by histone modifications that induce epigenetic changes on the genome. However, it is still not understood how ubiquitously expressed chromatin modifying complexes are 'guided' to specific genomic sites to induce intricate patterns of epigenetic modifications. Previously believed to represent 'genome junk', it is now becoming increasingly clear that large non-coding RNAs associate with chromatin modifying complexes. Here we explore an intriguing hypothesis that large non-coding RNA molecules might represent a molecular trafficking system that modulates chromatin modifying complexes to establish specific epigenetic landscapes.

Published by Elsevier Ltd.

PMID:
20362426
[PubMed - indexed for MEDLINE]
PMCID:
PMC2895502
Free PMC Article

Images from this publication.See all images (2)Free text

Figure 1
Figure 2
PubMed Commons home

PubMed Commons

0 comments
How to join PubMed Commons

    Supplemental Content

    Full text links

    Icon for Elsevier Science Icon for PubMed Central
    Loading ...
    Write to the Help Desk