Send to:

Choose Destination
See comment in PubMed Commons below
Appl Microbiol Biotechnol. 2010 May;86(6):1719-36. doi: 10.1007/s00253-010-2525-3. Epub 2010 Apr 2.

Unraveling polyketide synthesis in members of the genus Aspergillus.

Author information

  • 1Graduate Institute of Pharmaceutical Science, Chia Nan University of Pharmacy and Science, Tainan, 71710, Taiwan, Republic of China.


Aspergillus species have the ability to produce a wide range of secondary metabolites including polyketides that are generated by multi-domain polyketide synthases (PKSs). Recent biochemical studies using dissected single or multiple domains from PKSs have provided deep insight into how these PKSs control the structural outcome. Moreover, the recent genome sequencing of several species has greatly facilitated the understanding of the biosynthetic pathways for these secondary metabolites. In this review, we will highlight the current knowledge regarding polyketide biosynthesis in Aspergillus based on the domain architecture of non-reducing, highly reducing, and partially reducing PKSs, and PKS-non-ribosomal peptide synthetases.

[PubMed - indexed for MEDLINE]
Free PMC Article
PubMed Commons home

PubMed Commons

How to join PubMed Commons

    Supplemental Content

    Full text links

    Icon for Springer Icon for PubMed Central
    Loading ...
    Write to the Help Desk