Display Settings:

Format

Send to:

Choose Destination
We are sorry, but NCBI web applications do not support your browser and may not function properly. More information
Nat Cell Biol. 2010 Apr;12(4):314-5. doi: 10.1038/ncb0410-314.

Cilia self-organize in response to planar cell polarity and flow.

Author information

  • Department of Biochemistry & Biophysics, UCSF, San Francisco, CA 94158, USA. wallace.marshall@ucsf.edu

Abstract

Cilia drive fluid flow in development and physiology, but this requires that all cilia in a tissue orient the same way. Earlier studies indicated that both planar cell polarity (PCP) signalling and cilia-generated fluid flows could influence ciliary orientation. We now learn how asymmetric localization of PCP proteins influences the position and orientation of cilia to control the direction of flow.

Comment on

PMID:
20360747
[PubMed - indexed for MEDLINE]
PubMed Commons home

PubMed Commons

0 comments
How to join PubMed Commons

    Supplemental Content

    Icon for Nature Publishing Group
    Loading ...
    Write to the Help Desk