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Nat Cell Biol. 2010 Apr;12(4):314-5. doi: 10.1038/ncb0410-314.

Cilia self-organize in response to planar cell polarity and flow.

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  • 1Department of Biochemistry & Biophysics, UCSF, San Francisco, CA 94158, USA.


Cilia drive fluid flow in development and physiology, but this requires that all cilia in a tissue orient the same way. Earlier studies indicated that both planar cell polarity (PCP) signalling and cilia-generated fluid flows could influence ciliary orientation. We now learn how asymmetric localization of PCP proteins influences the position and orientation of cilia to control the direction of flow.

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