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J Nanosci Nanotechnol. 2010 May;10(5):3366-9.

Biodegradable nano-polymeric system for efficient Akt1 siRNA delivery.

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  • 1Department of Agricultural Biotechnology, Seoul National University, Seoul 151-921, Korea.

Abstract

Biodegradable nano-polymeric carrier composed of polycaprolactone (PCL) and polyethylenimine (PEI) (BNPP) was successfully synthesized for the delivery of sh/siRNA in lung cancer cells. BNPP efficiently and safely delivered siRNA in lung cancer cells. BNPP-delivered Akt1 siRNA silenced Akt1 protein, and reduced the cancer cell survival, proliferation, malignancy and metastasis.

PMID:
20358958
[PubMed - indexed for MEDLINE]
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