Warning: The NCBI web site requires JavaScript to function. more...
Generate a file for use with external citation management software.
Department of Surgery, Johns Hopkins Medical Institutions, Baltimore, Maryland.
Highly toxic metabolites of oxygen are generated normally by aerobic metabolism in most cells, and this generation is often greatly increased in pathologic conditions. When this oxidant flux exceeds the capability of the multiple endogenous antioxidant mechanisms, tissue injury ensues. The pharmacologic modification of this injury process, with agents that scavenge these reactive oxygen metabolites, block their generation, or enhance the endogenous antioxidant capability, has shown great promise in animal models of common clinical conditions, and has already been successfully applied in controlled clinical trials. This approach represents an interruption of tissue injury at its most basic level.
Your browsing activity is empty.
Activity recording is turned off.
Turn recording back on