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Exp Neurol. 2010 Jul;224(1):103-5. doi: 10.1016/j.expneurol.2010.03.016. Epub 2010 Mar 29.

Endocannabinoids and voluntary activity in mice: runner's high and long-term consequences in emotional behaviors.

Author information

  • 1RG Behavioral Biology, Department of Psychiatry and Psychotherapy, Central Institute of Mental Health (ZI), University of Heidelberg, Mannheim, Germany.

Abstract

The endocannabinoid system participates in the regulation of physical activity, although its role is not yet fully understood. Here, we highlight the impact of endocannabinoid signalling on voluntary wheel running in mice and discuss potential mechanisms involved such as hippocampal neurogenesis. Running-induced short-term and long-term alterations of emotional behaviors are scrutinized with regard to the question how endocannabinoids might be involved. While endocannabinoids seem to contribute to the motivational aspects of voluntary running in rodents, influencing the total distance covered most likely via CB1 receptors, they are less involved in the long-term changes of emotional behavior induced by voluntary exercise.

Copyright 2010 Elsevier Inc. All rights reserved.

PMID:
20353785
[PubMed - indexed for MEDLINE]
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