Am J Transplant. 2010 May;10(5):1117-25. Epub 2010 Mar 26.

Recent progress and new perspectives in studying T cell responses to allografts.

Valujskikh A, Baldwin WM 3rd, Fairchild RL.

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Department of Immunology and the Glickman Urological and Kidney Disease Institute, Cleveland Clinic, Cleveland, OH, USA. valujsa@ccf.org

Abstract

Studies in the past decade advanced our understanding of the development, execution and regulation of T-cell-mediated allograft rejection. This review outlines recent progress and focuses on three major areas of investigation that are likely to guide the development of graft-prolonging therapies in the future. The discussed topics include the contribution of recently discovered molecules to the activation and functions of alloreactive T cells, the emerging problem of alloreactive memory T cells and recently gained insights into the old question of transplantation tolerance.

PMID:: 20353479; [PubMed - indexed for MEDLINE]
PMCID:: PMC3208261

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